5-HT4 receptor (5ht4r_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT4 receptor
GENE
HTR4
ORGANISM
Human (Homo sapiens)
ALT. NAMES
5-hydroxytryptamine receptor 4, 5-HT-4, 5-HT4, Serotonin receptor 4
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
K
|
L
|
D
|
A
|
N
|
V
|
S
|
S
|
10 |
TM1 | |||||||||
E
|
E
|
G
|
F
|
G
|
S
|
V
|
E
|
K
|
V
|
20 |
V
|
L
|
L
|
T
|
F
|
L
|
S
|
T
|
V
|
I
|
30 |
L
|
M
|
A
|
I
|
L
|
G
|
N
|
L
|
L
|
V
|
40 |
M
|
V
|
A
|
V
|
C
|
W
|
D
|
R
|
Q
|
L
|
50 |
ICL1 | TM2 | ||||||||
R
|
K
|
I
|
K
|
T
|
N
|
Y
|
F
|
I
|
V
|
60 |
S
|
L
|
A
|
F
|
A
|
D
|
L
|
L
|
V
|
S
|
70 |
V
|
L
|
V
|
M
|
P
|
F
|
G
|
A
|
I
|
E
|
80 |
ECL1 | |||||||||
L
|
V
|
Q
|
D
|
I
|
W
|
I
|
Y
|
G
|
E
|
90 |
TM3 | |||||||||
V
|
F
|
C
|
L
|
V
|
R
|
T
|
S
|
L
|
D
|
100 |
V
|
L
|
L
|
T
|
T
|
A
|
S
|
I
|
F
|
H
|
110 |
L
|
C
|
C
|
I
|
S
|
L
|
D
|
R
|
Y
|
Y
|
120 |
ICL2 | |||||||||
A
|
I
|
C
|
C
|
Q
|
P
|
L
|
V
|
Y
|
R
|
130 |
TM4 | |||||||||
N
|
K
|
M
|
T
|
P
|
L
|
R
|
I
|
A
|
L
|
140 |
M
|
L
|
G
|
G
|
C
|
W
|
V
|
I
|
P
|
T
|
150 |
F
|
I
|
S
|
F
|
L
|
P
|
I
|
M
|
Q
|
G
|
160 |
ECL2 | |||||||||
W
|
N
|
N
|
I
|
G
|
I
|
I
|
D
|
L
|
I
|
170 |
E
|
K
|
R
|
K
|
F
|
N
|
Q
|
N
|
S
|
N
|
180 |
S
|
T
|
Y
|
C
|
V
|
F
|
M
|
V
|
N
|
K
|
190 |
TM5 | |||||||||
P
|
Y
|
A
|
I
|
T
|
C
|
S
|
V
|
V
|
A
|
200 |
F
|
Y
|
I
|
P
|
F
|
L
|
L
|
M
|
V
|
L
|
210 |
A
|
Y
|
Y
|
R
|
I
|
Y
|
V
|
T
|
A
|
K
|
220 |
E
|
H
|
A
|
H
|
Q
|
I
|
Q
|
M
|
L
|
Q
|
230 |
ICL3 | |||||||||
R
|
A
|
G
|
A
|
S
|
S
|
E
|
S
|
R
|
P
|
240 |
TM6 | |||||||||
Q
|
S
|
A
|
D
|
Q
|
H
|
S
|
T
|
H
|
R
|
250 |
M
|
R
|
T
|
E
|
T
|
K
|
A
|
A
|
K
|
T
|
260 |
L
|
C
|
I
|
I
|
M
|
G
|
C
|
F
|
C
|
L
|
270 |
C
|
W
|
A
|
P
|
F
|
F
|
V
|
T
|
N
|
I
|
280 |
ECL3 | |||||||||
V
|
D
|
P
|
F
|
I
|
D
|
Y
|
T
|
V
|
P
|
290 |
TM7 | |||||||||
G
|
Q
|
V
|
W
|
T
|
A
|
F
|
L
|
W
|
L
|
300 |
G
|
Y
|
I
|
N
|
S
|
G
|
L
|
N
|
P
|
F
|
310 |
H8 | |||||||||
L
|
Y
|
A
|
F
|
L
|
N
|
K
|
S
|
F
|
R
|
320 |
R
|
A
|
F
|
L
|
I
|
I
|
L
|
C
|
C
|
D
|
330 |
C-term | |||||||||
D
|
E
|
R
|
Y
|
R
|
R
|
P
|
S
|
I
|
L
|
340 |
G
|
Q
|
T
|
V
|
P
|
C
|
S
|
T
|
T
|
T
|
350 |
I
|
N
|
G
|
S
|
T
|
H
|
V
|
L
|
R
|
D
|
360 |
A
|
V
|
E
|
C
|
G
|
G
|
Q
|
W
|
E
|
S
|
370 |
Q
|
C
|
H
|
P
|
P
|
A
|
T
|
S
|
P
|
L
|
380 |
V
|
A
|
A
|
Q
|
P
|
S
|
D
|
T
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
5-hydroxytryptamine
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page